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In fact, one study found that peoples bodies absorbed about 49% of a 1-mcg dose of cyanocobalamin, compared to 44% of the same dose of methylcobalamin ( Conversely, another study comparing the two forms reported that about three times as much cyanocobalamin was excreted through urine, indicating that methylcobalamin may be retained better within your body ( However, some research suggests that differences in bioavailability between the two forms may be insignificant and that absorption could be influenced by factors such as age and genetics ( Unfortunately, recent research directly comparing these two forms of vitamin B12 is limited

Appreciation is extended to Supaphich Suksa, PharmD, for critical review of the manuscript, and to the Guest Editor(s) for the invitation to contribute to the special collection Women in Translational Neuroscience 2025

At Hispano Medical Centers, our skilled physicians educate and treat Vitamin B12 deficiencies personally