In Vitro: Dihexa binds with high affinity to HGF and both dihexa and its parent compound Norleucine 1-AngIV induce c-Met phosphorylation in the presence of subthreshold concentrations of HGF and augment HGF-dependent cell scattering. Further, dihexa and Nle1-AngIV induce hippocampal spinogenesis and synaptogenesis similar to HGF itself. Dihexa effectively inhibits HGF dimerization at 1 M. While dihexa at 1 nM and 10 pM alone does not activate c-Met, it markedly augments the capacity of HGF at 1.25 and 2.5 ng/mL to activate c-Met
Who Should Exercise Particular Caution: Pregnant or Nursing Women: No safety data exists for BPC-157 use during pregnancy or lactation
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Tesamorelin (elimination half-life approximately 8 minutes after subcutaneous administration, once-daily dosing, FDA-approved, Phase 3 visceral fat data) and CJC-1295 (DAC-modified, approximately 8-day half-life, once-weekly dosing, no approved indication) represent fundamentally different engineering approaches to GHRH agonism [5]
