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Glutathione reductase (GR), an NADPH-dependent enzyme, continuously regenerates reduced glutathione (GSH) from its oxidized form (GSSG), thereby maintaining the intracellular reducing environment required for effective antioxidant defense, proper enzymatic activity, and redox-dependent signaling pathways [36]

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Treatment of the root cause This might mean treating celiac disease, adjusting medications, or managing autoimmune conditions like pernicious anemia

[DOI] [PMC free article] [PubMed] [Google Scholar] 18.Lang CA, Mills BJ, Lang HL, Liu MC, Usui WM, Richie JP, Jr, Mastropaolo W, Murrell SA