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Accordingly, a short-term DMF treatment of an oligodendrocyte cell line did not prevent a hydrogen peroxide-mediated death, and a DMF treatment in a model of toxic demyelination was not able to prevent demyelination (41)

Data were expressed as permeability (Papp) calculated using the following formula: where dQ/dt, rate of permeation C 0 , initial concentration of compound A, area of monolayer (0.11 cm 2 ) Efflux Ratio (R e ) was calculated using the formula: 5.2