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Abbreviations 2SC: 2-succinyl-cysteine aKG: Alpha-ketoglutarate ARA+EPA: Arachidonic acid and eicosapentaenoic acid ATP: Adenosine triphosphate ATS: American Thoracic Society AUC: Area under the receiver operating characteristic curve BC-CCI: British Columbia Cognitive Complaints Inventory bp: Base pair C: Cholesterol CK: Creatine kinase CMC: Carboxymethyl-cysteine CML: Carboxymethyl-lysine CPCA: Consensus principal component analysis DHA: Docosahexaenoic acid D LCO : Lung diffusing capacity for carbon monoxide DLN: Dry low nitroxides EC: Esterified cholesterol edf: Effective degrees of freedom FACIT: Functional Assessment of Chronic Illness Therapy FC: Free cholesterol GAM: Generalized additive modeling Glyc: Glycoprotein GC/MS: Gas chromatographymass spectrometry H-NMR: Proton nuclear magnetic resonance spectroscopy H/W: Height to bandwidth HADS: Hospital Anxiety and Depression Scale HACA: Aminocaproic acid HAVA: Aminovaleric acid ICU: Intensive care unit IDL: Intermediate-density lipoprotein IS: Internal standard LA: Linoleic acid LDL: Low-density lipoprotein LMWM: Low molecular weight metabolites LOESS: Locally Weighted Scatter-plot Smoother LOOCV: Leave-one-out cross validation LPC: Lysophosphatidylcholine MDAL: Malondialdehyde-lysine ML: Machine learning mMRC: Modified Medical Research Council MSD: Mass selective detector NIST: National Institute of Standards and Technology NRL: L-norleucine OXPHOS: Oxidative phosphorylation P: Particle number PASC: Post-acute sequelae of COVID-19 PBS: Phosphate buffer solution PCA: Principal component analysis PL: Glycerophospholipids, except LPC PLS-DA: Partial least square discriminant analysis PUFA: Polyunsaturated fatty acids RF: Random forest ROC: Receiver operating characteristic ROS: Reactive oxygen species SF-12: Mental and physical scores from the 12-Item Short Form Survey SIM: Selecting ion monitoring TCA: Tricarboxylic acid TFAME: N,O-trifluoroacetyl methyl ester TG: Triglycerides VLDL: Very low density lipoprotein W3: Omega-3 fatty acids w6+w7: Omega-6 and omega-7 fatty acids W9: Omega-9 fatty acids WHO: World Health Organization Z: Diameter References Soriano JB, Murthy S, Marshall JC, Relan P, Diaz J V

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A person weighing 180 pounds burns fewer calories at rest than when they weighed 230 pounds

Treatment modalities involving the administration of ferroptosis inhibitors, GPX4 activators, and classical and modern interventions, such as Jianwei Shoutai Pill and ferrostatin-1, now offer new avenues to modulate