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Overlap statistics were higher (range 0.600.70) when comparing PRO measures in patients with high versus low BSA involvement, indicating that a randomly selected patient with high BSA involvement would have at least the same or greater impairment in quality of life and symptom burden as a patient with low BSA involvement in 6070% of comparisons

It has been demonstrated to upregulate the expression of tight junction proteins (e.g., ZO-1, occludin) and prevent their degradation following I/R injury

That said, our thinking when we developed these approaches was shaped by the form and nature of the Advanced APMs that existed at that time

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