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It predicted four functional domains of GSR, which are pyridine nucleotide-disulfide oxidoreductase domains and FAD/NAD(P)-binding domains (65390), and demonstrated that all 4 nsSNPs identified are positioned on these domains (Fig

We highlight some methodological aspects of relevance in the interpretation of in vitro testing results, including limitations and strengths, offering a critical viewpoint for the implementation of future pharmacological studies aimed to the discovery and characterization of novel treatments for NS