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Folic acid prevents cardiac dysfunction and reduces myocardial fibrosis in a mouse model of high-fat diet-induced obesity

DSIP crosses the blood-brain barrier through a saturable transport system, confirming it is actively transported into the brain rather than passively diffusing across

this does not establish efficacy or long-term safety

This tolerance-building process is analogous to allergy immunotherapy, where repeated exposure to an allergen gradually desensitizes the immune system