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Early evidence already suggests that such multiplex regimens outperform single-agent therapy where metabolic heterogeneity blunts isolated responses (81, 85) (Table 3) Future work must dissect mechanism-specific dosing ratios, develop quantitative biomarkers of combinatorial efficacy, and deliver large, stratified, randomized trials to confirm both safety and clinical relevance

Early treatment is essential as delayed therapy can result in incomplete recovery or permanent damage

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These studies provide the highest level of clinical evidence available for any GHRH analogue