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Other modified proteins were extracellular matrix proteins and proteins involved in the degradation thereof (such as Col6a1 , Ctsb , Ctsd , Hspg2 , Plg , and Vtn ) and cytoskeletal proteins (such as Flna, Syne2 , Tbcc , and Lpp )

The pathology of AD is characterized by the accumulation of extracellular amyloid (A) plaques and the formation of intracellular neurofibrillary tangles composed of hyperphosphorylated tau protein (38)

[DOI] [PMC free article] [PubMed] [Google Scholar] 559.Zhu C., Zhang S., Song C., Zhang Y., Ling Q., Hoffmann P.R., Li J., Chen T., Zheng W., Huang Z

619 In a randomized, placebo-controlled, crossover trial, 23 individuals with coronary artery disease received 200 mg pycnogenol daily for eight weeks followed by placebo for eight weeks, or vice versa