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CANE demonstrated substantial anticancer efficacy against DOX-resistant A549 lung carcinoma cells (A549DR), promoting apoptosis as shown by elevated levels of Bax, Cytochrome C, and cleaved caspases 3 and 9

157 This variant also lacks tight DNA binding ability and coordination with BER steps, causing DNA damage accumulation and genomic instability, particularly under inflammatory conditions due to tumor necrosis factor-alpha (TNF-)-induced oxidative stress and NO release

Living organisms possess their unique regulatory mechanisms for the aggregation of internal biomolecules 6,7 , including the formation of hierarchical protein structures 8 and the assembly and disassembly of chromatin, etc 9

Concomitant use of other paracetamol-containing products or use of other cold and cough medicines, including cough suppressants and sympathomimetics (decongestants, appetite suppressants and amphetamine-like psychostimulants), should be avoided