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These anti-inflammatory and antioxidant effects translate into histological protection (less neuronal loss) and functional improvements in motor behavior

Persons with chronic HBV infection (HBsAg positive), as well as those with resolved HBV infection (HBsAg negative and anti HBc positive), are at risk for reactivation of HBV, with risk depending both on an individual's HBV serologic status, and their type of immunosuppression

Loss of GPX4 protein expression in NRF1-deficient cells sensitized cells to ferroptosis, whereas in cells lacking GPX4, overexpression of NRF1 failed to inhibit ferroptosis