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Because cystine is dominant in cell culture media, xCT expression is commonly induced in most types of cells, whether lined or primary, to meet the Cys requirement and support their survival [48]

In conclusion, while the FRAP assay is simple and economical, its results should be interpreted cautiously, particularly in comparison to other assays, due to its limitations in addressing reaction kinetics, specificity, and interferences (Magalhaes et al

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Accordingly, metabolites with high positive and negative factor loading in PC1 tended to increase and decrease with PR8 virus infection, respectively (Table 1)