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As the main transcription factor of Th17 cell, RORt collaborates with other transcription factors, such as ROR, IRF4, and Runx1, to synergistically stimulate Th17 cell growth and IL-17 release ( Foxp3 interacts with several transcription factors, such as STAT5, NFAT, and BACH2, to influence the Treg cells' development, stability, and epigenetic modifications