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Under normal physiological conditions, mitochondria produce a small amount of reactive oxygen to participate in intracellular signal transduction, while mitochondrial dysfunction can lead to the production of large amounts of reactive oxygen, triggering oxidative stress damage and contributing to neurological diseases ( 4.2.3 Damage to the intestinal barrier and disruption of the gut-brain axis In recent years, the gut microbiome-gut-brain axis has become an important field in biological research

Licorice may exert therapeutic effects on diabetes and its complications through anti-inflammatory or antioxidant mechanisms (140)

IL-22 upregulates the expression of CXCL13 in fibroblasts and CXCL12 in epithelial cells, thus exerting a pro-fibrotic effect (43)

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