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Its core pathogenesis involves the interplay of three key processes: immune dysregulation that is characterized by Treg dysfunction and B-cell hyperactivation, vascular endothelial injury and dysfunction, and abnormal fibroblast proliferation (226)

The systems were then heated for 100 ps by incrementing the temperature from 0 to 300 K under a constant pressure of 1 atm and periodic boundary conditions with a timestep of 1 fs

If it has been stored improperly or past the expiration date, it may also not work as well

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