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Joint damage prevention ultrasound imaging in the NOR-Gout study demonstrated resolution of crystal deposits (double contour sign) in 83.4% of patients and dissolution of tophi in 63.2%, confirming that sustained treatment can reverse, not just halt, the structural damage of chronic gout

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Pregnant women should only use these medications under strict OB supervision, since dehydration from severe diarrhea threatens fetal health and amniotic fluid levels

The metathesis reaction was applied to obtain a series of macrocyclic compounds, devoid of the reactive disulfide function and with the potential to become oral bioavailable and more metabolically stable (Driggers et al., 2008