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Godau 2011)

[22] where they compared patients who underwent PRP with patients who underwent dry needling showing better results in the patients infiltrated for the VISA-P score at about 12 weeks, but with results superimposed on the control at 26 weeks

This compromised barrier facilitates the systemic translocation of immunostimulatory microbial derivativesparticularly endotoxin (LPS) and pro-fibrotic oxidized trimethylamine N-oxide (TMAO)which drive cardiac fibroblast activation, collagen deposition, and adverse myocardial remodeling

However, sensitive skin users are advised to conduct a patch test first, starting with low concentrations (below 0.5%) to build tolerance