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Ergothioneine is taken up by endothelial cells via SLC22A4 (Reference Li, Yang and Sit88) , where it has been demonstrated to limit reactive oxygen species production and damage from a variety of insults, including hyperglycaemia, through multiple mechanisms (Reference Li, Yang and Sit88,Reference DOnofrio, Servillo and Giovane89)

Tumor-associated macrophages produce interleukin 6 and signal via stat3 to promote expansion of human hepatocellular carcinoma stem cells

Common symptoms include: Fatigue and weakness Anemia Neurological issues such as numbness or tingling in the hands and feet Cognitive difficulties and memory problems Glossitis and mouth ulcers Moreover, prolonged deficiency can lead to severe health complications, such as pernicious anemia and neurological damage

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