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Conclusion: AOD 9604 not only promotes weight loss, but also effectively prevents and reverses bone loss during the weight loss period, achieving a dual benefit of "weight loss+bone protection"

In obese individuals with hyperinsulinemia, hepatic GHR expression is enhanced as indicated by elevated GHBP levels reflecting proteolytic cleavage of highly expressed surface GHR and release of the extracellular part to the circulation (65)

Exercise and muscle preservation Resistance training is the single most important addition to a tirzepatide protocol for optimizing body composition

J Clin Pharmacol 41:636644 Trenkwalder C, Chaudhuri KR, Martinez-Martin P, Rascol O, Ehret R, Valis M, Satori M, Krygowska-Wajs A, Marti MJ, Reimer K, Oksche A, Lomax M, DeCesare J, Hopp M, group Ps (2015) Prolonged-release oxycodone-naloxone for treatment of severe pain in patients with Parkinsons disease (PANDA): a double-blind, randomised, placebo-controlled trial