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Currently developed DPP1 inhibitors are all oral formulations, while many NSP inhibitors require inhalation administration ( However, DPP1 inhibition also has some potential disadvantages, including slower onset (approximately 20 days to achieve maximum effects) and possible systemic side effects such as hyperkeratosis and periodontitis

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Conversely, correlation analysis showed that the metabolic correlation co-effects were higher in the serum of both LPS- and papain-induced pneumonia groups than in the control group, indicating common systemic metabolic alterations in both models (Figure 1C)