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doi: 10.1016/j.phymed.2025.156873 134 Del CuoreAPipitoneRMCasuccioAMazzolaMMPuleoMGPacinellaGet al

Glycitin Induced Autophagy to Clear Amyloid Beta and Protects Neuronal Cell in Alzheimers Disease

While analogs with reduced IGFBP affinity show increased potency in vitro, careful pharmacokinetic work has shown that such analogs are actually cleared more rapidly than native IGF-1 after parenteral administration in vivo, because the binding proteins that inhibit activity also serve as a circulating reservoir that prolongs systemic presence

The present data also show that cAMP induction by exenatide, forskolin, and GIP induces frataxin protein expression in rat, mouse, and human cells without affecting frataxin mRNA (Figure 2, Figure 3, Figure 4, Figure 5, Figure 6, Supplemental Figure 3, Supplemental Figure 6, and Supplemental Figure 7)