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These results have been replicated multiple times

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S., Effects of Mesenchymal Stem CellDerived Nanovesicles in Experimental Allergic Airway Inflammation, Respiratory Research 24 (2023): 3

While Grn homozygous null ( Grn / ) mice are viable and fertile, they exhibit several features of FTLD- GRN and CLN11 including lysosomal dysregulation, lipofuscinosis, neuroinflammation, synaptic loss, retinal ganglion cell (RGC) loss, and obsessive compulsive disorder (OCD)-like behavior as well as social deficits [16, 88, 137, 174,175,176,177] and therefore have been widely used as a model of FTLD- GRN and CLN11