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Using three cancer models, we show that induction of senescence by either palbociclib or cisplatin makes tumours sensitive to GPX4 inhibitors at concentrations at which toxicities are spared

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Mild drowsiness or fatigue Increased sense of calm that may manifest as mild drowsiness in some individuals, particularly at higher doses

In this study, despite the limitations described, our observations highlight significant proteomic changes in chondrocytes under oxidative stress, including ER dysfunction and impaired ECM protein secretion, offering a deeper understanding of how redox imbalances affect chondrocyte function