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Combined thyroxine/liothyronine treatment does not improve well-being, quality of life, or cognitive function compared to thyroxine alone: a randomized controlled trial in patients with primary hypothyroidism

For example, KMO deficiency in male mice elevates KYNA and induces depressive-like behaviours via 7nAChR antagonism, impairing cholinergic modulation of prefrontal circuits, effects that are reversed by restoring 7nAChR signalling [71]

Additionally, they suggested that silibinin could inhibit the proliferation of human endometriosis cells by regulating the MAPK signaling pathway

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