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Notably, the conditional knockout (cKO) of Dnmt1 using the Chx10-Cre line led to the rapid death of photoreceptors and other neuronal cell types at birth, while the differentiation process of RPCs remains unaffected (Rhee et al., 2012)

The absence of biotin affects the expression of transcription factors like NF-B and SP1/3, indicating that biotin regulates immunological phenomena via mechanisms besides carboxylation and decarboxylation (152) ( Table 2 )