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If any markers show negative changes, extend time off before considering another cycle

Neurologic symptoms The neurologic symptoms of vitamin B 12 deficiency are myriad and include numbness and tingling of the hands and, more commonly, the feet (peripheral neuropathy)

Pozzi V, Mazzotta M, Muzio LL, Sartini D, Santarelli A, Renzi E, Rocchetti R, Tomasetti M, Ciavarella D, Emanuelli M (2011) Inhibiting proliferation in KB cancer cells by RNA interference-mediated knockdown of nicotinamide N-methyltransferase expression

This means it prevents any introduced bacteria from reproducing, making it safe for multi-draw research vials over a 28-day period