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The prolonged nature of chronic wound healing also poses challenges in terms of infection control and microbial management, as biofilms and persistent pathogens complicate the healing process

In addition, macrophages secrete sphingomyelinase, which has been reported to act synergistically with LPL to promote binding of LDL and lipoprotein (a) (Lp(a)) to vascular smooth muscle cells (VSMC) and the extracellular matrix promoting their retention in the artery (239,240)

There is no FDA-approved testosterone product for women in the United States, despite strong evidence supporting low-dose testosterone for hypoactive sexual desire, energy, and musculoskeletal health in perimenopausal and postmenopausal women

When intermittently activated, they inhibit cell proliferation