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T cells accumulate in the intestine before arthritis onset To investigate cellular intestinal alterations that precede the onset of arthritis in more detail, we analyzed T-cell subsets in the intestine at different time points during the CIA time course

This also highlights the need for consideration of haem source in in vitro models, where free haem is typically added as the sole source in culture media: a condition which may not reflect predominant sources in the respiratory and middle ear niches

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