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The combined model output was validated by replicating Figs 2 and 6 from the Reed et al

10.1124/jpet.109.152017 18 ChenD

The granuloma is composed of epithelioid histiocytes and multinucleated giant cells, which will contain M

Introduction Psoriasis is an immune-related chronic inflammatory disease in connection with hyperproliferation of keratinocytes and inflammatory infiltration, which is induced by immune mediators especially for IL-23/Th17 axis ( The overloaded reactive oxygen species (ROS) in psoriatic lesions disequilibrates the redox system ( A new generation of small-molecule drugs have mostly been developed as oral formulas ( However, because of the lipophilic property of Deucravacitinib, it is difficult to penetrate the complex hydrophobic and hyperproliferative SC barrier, which is the primary challenge in the development of a topical therapeutic agent for psoriasis ( 4 O 2 -SACs) ( In this study, to control the biodistribution of Deucravacitinib targeting excessive ROS in the psoriatic SC layer, we synthesized Deucravacitinib-loaded poly(ethylene glycol)-b-poly(propylene sulfide) (PEG-b-PPS) diblock copolymers (Deu@PEPS)