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The most important serious side effects include acute pancreatitis (severe persistent abdominal pain radiating to the back, though clinical trials found similar pancreatitis rates to comparators), severe dehydration from persistent vomiting or diarrhea (signs include dizziness, decreased urination, extreme thirst), gallbladder disease including cholecystitis or cholelithiasis (right upper quadrant pain, fever, jaundice), severe allergic reactions (difficulty breathing, swelling of face or throat), and severe hypoglycemia when combined with insulin or sulfonylureas (confusion, loss of consciousness, seizures)

Peroxisomal H 2 O 2 metabolism is usually related to the regulation of peroxisomal functions and is also important for extra-peroxisomal redox targets, such as FOXO3, the master regulator of ROS

This interpretation was further supported by our functional assays, which demonstrated significantly reduced production of IL-5, IL-6, IL-9, IL-10, and IL-13 by melatonin-treated ILC2s