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Key points Established therapies for pulmonary arterial hypertension (PAH), which has a complex vascular pathobiology characterized by cell proliferation, extracellular matrix deposition and inflammation, have predominantly vasodilatory effects

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At the genus level, Secukinumab treatment led to an increase in the relative abundance of Bacteroides, Prevotella, Roseburia, Lachnoclostridium , and Phascolarctobacterium , while Faecalibacterium, Agathobacter, Megamonas, Dialister , and Escherichia-Shigella decreased ( Figure 6B )