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[2] Glutathione (GSH) was first discovered by Hopkins [3] in 1921 in yeasts, and subsequently in other tissues

While the molecular pathogenesis of AxD remains incompletely understood, massive reactive astrogliosis with Rosenthal fibers composed of aggregated GFAP, vimentin, nestin, B-crystallin and small heatshock proteins together with prominent leukodystrophy are the pathological hallmarks, with the pathophysiological picture including mitochondrial malfunction, redox imbalance and susceptibility to oxidative stress 331,332,333

doi: 10.1016/j.jhep.2016.04.025

When mitochondrial function is compromised by oxidative stress, cellular processes slow down, leading to decreased collagen production, impaired barrier function, and reduced skin hydration