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This reaction is particularly important in sulfonamide metabolism because acetyl-sulfonamides have reduced solubility and can lead to precipitation, especially in the kidneys, leading to renal toxicities 5.4 Drug Metabolism Exploits Ubiquitous Themes in Chemistry One of the remarkable features of hepatocytes and drug metabolism within the body is that there is a high efficiency and capacity to metabolize foreign molecules with a wide range of chemical diversity