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(2019) demonstrated that Hyp protects against I/R-induced tubular cell injury through its influence on mitochondrial fission, OS, and apoptosis

and in vivo, long-acting GHRH treatment also induced pituitary DNA damage in mice

The similarity of some aspects of the inhibition of the mitochondrial transporter with those previously found for the plasma membrane OCTN2 transporter, which however were not described at the molecular level [19], indicates that the substrate binding sites should have some similar properties, in spite of the very different primary structures and affinity for substrates of the two proteins

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