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As an example, in response to gram-negative LPS, TNF- induces upregulation of macrophage G6PD expression and activity ( 2.3 Effect of G6PD deficiency on innate immune system function and disease Given the role of G6PD in phagocyte effector function, in the 1960s, it was theorized that G6PD deficiency might impact susceptibility to sepsis and meningitis ( Clinically, there is much interest in understanding the role that G6PD deficiency and an associated aberrant innate immune effector response might play in childhood sepsis

Ann for Res 52(1):129136

Each treatment group and hen was identified by the neck tag and recorded

A recent study shows that IL-22 expression is significantly increased in the liver of female mice with APAP-induced hepatotoxicity, indicating the necessity to consider gender-dependent effects when using mice to establish a pathophysiological model of IL-22 [205]