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Outre la caractristique commune de toute anmie (diminution du nombre de globules rouges), lanmie due une carence en B12 prsente un phnomne de macrocytose (augmentation de la taille des globules rouges ou rythrocytes) qui se manifeste par une croissance anormale des cellules sanguines (les fameux mgaloblastes), due une absence de maturation du noyau et une augmentation de la masse et de la maturation cytoplasmique