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Larger stimuli could activate the inhibitory surround, thereby decreasing the response to information in the centre

US Navy Diving Manual Rev

E., McReynolds M

In the last years, several reports have shown that sublethal concentrations of ROS trigger a retrograde response that not only increases lifespan in different animal models, from worms to mammals, but also enhances healthspan, particularly improving metabolism and immune system 51,71,72,73