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If symptoms significantly impact daily functioning beyond the first week at a new dose, consider extending that dose level for an additional four weeks before increasing

For menopausal women, tirzepatide may have an edge over semaglutide because GIP receptors are found in adipose tissue and may directly influence fat metabolism beyond what GLP-1 alone can achieve

Moreover, the epigenetically-modified phenotype can potentially disappear within a generation, or wash in or wash out over multiple generations (Figure 6B)

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