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In particular, the major histological changes in early DKD include tubular cell hypertrophy, thickening of the tubular basement membrane and interstitial inflammation with mononuclear cell infiltration

Recommendation 5: Liver biopsy should be considered in HCC patients receiving molecular targeted therapy and/or ICIs under the following conditions: (1) Liver injury cannot be clearly attributed to anti-tumor therapy, necessitating further investigation

Topical formulations are designed for localized treatment, whereas transdermal systems are intended to achieve systemic effects

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