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This dysfunction may be caused by the inhibition of multiple enzymes and/or transporter proteins involved in fatty acid -oxidation metabolism by VPA ( Studies on the inhibitory effect of VPA on mitochondrial fatty acid -oxidation have shown that VPA has different inhibitory effects on fatty acid oxidation of different chain lengths

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Lateef OM, Akintubosun MO

The attenuation of the anticonvulsant effect of valproic acid and increased risk of serotonin syndrome after antidepressants from the selective serotonin reuptake inhibitor and monoamine oxidase inhibitor groups have also been described in situations when these drugs were combined with Ginkgo biloba preparations [84,85,86]