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[DOI] [PubMed] 102.Taranukhin A.G., Taranukhina E.Y., Saransaari P., Podkletnova I.M., Pelto-Huikko M., Oja S.S

With each 100 mg increase in opioids cumulative dose before weaning, the study found a 10% increase in the odds of probable withdrawal syndrome (OR = 1.10

doi: 10.1038/s12276-020-0437-6 572 ZaviiGRistiSPetkoviBivkov-aponjaDJojiNJankoviD

One study, which also evaluated cognitive function in patients with high MMA concentrations, found no significant effects on the MDD inventory score, but only 30 of the 140 subjects had depression at baseline, which may have diluted any benefits