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[DOI] [PMC free article] [PubMed] [Google Scholar] 41.Choo H.J., Kholmukhamedov A., Zhou C., Jobe S

Do not exceed 400 mg in adults within 24 hours, as higher exposure correlates with delirium, seizures, and cardiotoxicity

This was corroborated by observations of embryonic lethality in mouse and Caenorhabditis elegans models, with oxidative stress damage shown to be the underlying cause (31)