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NEAAs may influence tumor progression through macromolecule biosynthesis, maintenance of redox homeostasis, and numerous allosteric and epigenetic regulatory mechanisms [60]

Moreover, UMOD overexpression correlates with diminished UA excretion, renal fibrosis, immune cell infiltration, and progressive renal failure

Mutations in genes affecting the production of this enzyme can have a significant impact on the function of the MTR enzyme and thus recycling of homocysteine back into methionine (13)