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1 Oxidation-driven storage lesion and its post-transfusion impact 1.1 Oxidative stress as a driver of storage lesions in red blood cells During their hypothermic storage, red blood cells (RBCs) accumulate a wide array of defects, collectively known as storage lesion

In laboratory research, glutathione is extensively studied for its roles in phase II xenobiotic metabolism, where it conjugates with reactive electrophiles via glutathione S-transferase enzymes

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Therefore, the toxicity of the different ions of the metals needs to be included into consideration when planning the uptake and processing of these ions as a substrate for metal nanoparticle (NP) production by bacteria