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Although these mice and, later, gut-corrected ( Cftr tm1Unc -TgN(FABPCFTR) mice did show excessive proinflammatory signaling with increased chemokine (C-X-C motif) ligand 1 (CXCL1 or KC), TNF and PMN recruitment into the airways and increased weight loss during the course of infection, they spontaneously cleared even large inocula of typical cystic fibrosis pathogens

ISBN-13: 978-1118430354 ISBN-10: 1118430352 Watanabe K, Shoja MM, Loukas M, Tubbs RS