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This rate-limiting step is catalyzed by glutamate-cysteine ligase (GCL) a heterodimeric enzyme composed of a catalytic subunit encoded by GCLC and a modifier subunit encoded by GCLM

doi: 10.3389/fnut.2026.1774375 Received 23 December 2025 Revised 22 January 2026 Accepted 26 January 2026 Published 17 February 2026 Volume 13 - 2026 Edited by Abul Hossain, University of British Columbia, Canada Reviewed by Changbao Sun, Qiqihar University, China Suresh Kumar, National Institute of Biologicals, India Updates Copyright 2026 Egas-Montenegro, Echeverria-Chilla, Garca-Ulloa, Aizaga-Benalcazar and Ordoez-Araque

Formation of intracellular aggregates of various crystallin proteins was visualized by fluorescence of GFP (green) and the nuclei were stained with Hoechst 33342 (blue)