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These associated ailments include, but are not limited to, psoriatic arthritis, cardiovascular issues, metabolic disorders such as diabetes, non-alcoholic hepatic steatosis, and inflammatory conditions affecting the gastrointestinal tract (3)

Numerous methods rely on classical cheminformatics and computer-aided drug discovery tools to predict the biological activity of drugs

( mRNA quantification by quantitative real-time PCR (qRT-PCR) Total RNA was isolated using QIAzol-Reagent (Qiagen, Germany), based on modified Chomczyski & Sacchis method (Chomczynski and Sacchi, 2006), following the manufacturers protocol

Nitrosoureas are a group of alkylating agents that can cross the bloodbrain barrier (BBB) and are cell phase non-specific and lipid soluble [38]