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The Best-1 channels are localized in astrocytic leaflets and are opened by relatively moderate increases in [Ca 2+ ] i at the resting membrane potential 89

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To protect against drug toxicity, tumor cells usually alter metabolic pathways, including the glycolytic pathway, glutamine metabolism pathway, serine synthesis pathway, oxidative phosphorylation (OXPHOS) pathway, pentose phosphate pathway (PPP), fatty acid oxidation pathway, and methionine metabolism pathway

Excess ROS in the ovary deteriorates oocyte competence, induces GCs apoptosis, disrupts GCsoocyte communication, alters cytoskeletal and spindle assembly dynamics, and accelerates ovarian aging through mitochondrial dysfunction, telomere shortening, inflammation, and apoptosis (Prasad et al., 2016