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These findings together suggest that EZH2/H3K27me3 plays a role in liver failure by regulating immune activation, as evidenced by the fact that GSK126-induced inhibition of EZH2-catalyzed H3K27me3 can significantly attenuate liver injury and reduce inflammatory cell infiltration

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Early work demonstrated that BSCs could be described by two independent parameters, suggesting a linear model fit for BSC-frequency relationships in the liver 39